反应详情

N-Methyl-4-benzyloxyphenylcyanamide (3.6 g) was added to a suspension of 2-aminobiphenyl hydrochloride (3 g) in m-cresol (8 ml) and the mixture was heated at 90°-95° C. for 3 hours and then added to water. The aqueous layer was basified with solid sodium bicarbonate and extracted with ether. The extract was dried (Na2SO4) and the solvent removed to give a residue which was extracted into boiling hexane to yield N-(4-benzyloxyphenyl)-N'-(2-biphenylyl)-N-methylguanidine.

1. temperaturethe mixture was heated at 90°-95° C. for 3 hours
2. extractionextracted with ether
3. dry with materialThe extract was dried (Na2SO4)
4. customthe solvent removed
5. customto give a residue which
6. extractionwas extracted