Water → HCID 178485093, compound

HRID 1464064Notes

Reaction equation

HRID 1464064 reaction equation
[CH3:1][N:2]([C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:7][CH:6]=1)[C:3]#[N:4].Cl.[NH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1.O.C(=O)(O)[O-].[Na+]>C1C(O)=CC=CC=1C>[CH2:12]([O:11][C:8]1[CH:9]=[CH:10][C:5]([N:2]([CH3:1])[C:3]([NH:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=2[C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=2)=[NH:4])=[CH:6][CH:7]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

6

Reactant 4

HCID 962WaterHCID 516892Sodium BicarbonateHCID 52843472-Biphenylamine hydrochlorideHCID 19089199N-methyl-4-benzyloxyphenylcyanamide

Product 1

HCID 178485093HCID 178485093, compound

Reagents, catalysts & solvents 1

HCID 342M-CresolSolvent

Procedure

N-Methyl-4-benzyloxyphenylcyanamide (3.6 g) was added to a suspension of 2-aminobiphenyl hydrochloride (3 g) in m-cresol (8 ml) and the mixture was heated at 90°-95° C. for 3 hours and then added to water. The aqueous layer was basified with solid sodium bicarbonate and extracted with ether. The extract was dried (Na2SO4) and the solvent removed to give a residue which was extracted into boiling hexane to yield N-(4-benzyloxyphenyl)-N'-(2-biphenylyl)-N-methylguanidine.

Workup

  1. temperaturethe mixture was heated at 90°-95° C. for 3 hours
  2. extractionextracted with ether
  3. dry with materialThe extract was dried (Na2SO4)
  4. customthe solvent removed
  5. customto give a residue which
  6. extractionwas extracted

Sources & evidence

ORD record
ord-f36152bd29b742c79ed847710d8d8081
Source dataset
uspto-grants-1994_04
Patent number
US05302720

Reaction notes

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