2-Aminobiphenyl → 1-Isothiocyanato-2-phenylbenzene

HRID 1464068Notes

Reaction equation

HRID 1464068 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[C:14](Cl)(Cl)=[S:15]>O1CCOCC1.O>[C:3]1([C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:2]([N:1]=[C:14]=[S:15])=[CH:7][CH:6]=[CH:5][CH:4]=1

Participants

5

Reactant 2

HCID 70152-AminobiphenylHCID 10040Thiophosgene

Product 1

HCID 5196591-Isothiocyanato-2-phenylbenzene

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 312751,4-DioxaneSolvent

Procedure

Reaction of 2-aminobiphenyl (10 g) with thiophosgene (10.2 g) in a mixture of dioxane (15 ml) and water (50 ml) at 0°-5° C. for 30 minutes and at ambient temperature for 2 hours with stirring gave 2-biphenylylisothiocyanate as a yellow oil.

Sources & evidence

ORD record
ord-d753fb2fe9f74e71b25a946ebc5261d1
Source dataset
uspto-grants-1994_04
Patent number
US05302720

Reaction notes

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