Potassium Hydroxide → HCID 19089303, compound

HRID 1464075Notes

Reaction equation

HRID 1464075 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[C:4]([NH:14][C:15]([NH2:17])=S)[CH:3]=1.[OH-].[K+].O.O.O.C([O-])(=O)C.[Pb+2].C([O-])(=O)C>O>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[C:4]([NH:14][C:15]#[N:17])[CH:3]=1

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 22456Lead diacetate trihydrateHCID 19089278HCID 19089278, compound

Product 1

HCID 19089303HCID 19089303, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent3×

Procedure

A suspension of N-(4-fluoro-2-biphenylyl)thiourea (11 g) in water (70 ml) was reacted with a solution of potassium hydroxide (25.2 g) in water (70 ml). Lead acetate trihydrate (17 g) in water (70 ml) was added and the reaction mixture heated at 90°-95° C. for 40 minutes to give 4-fluoro-2-biphenylylcyanamide (m.p. 68°-70° C.).

Workup

  1. temperaturethe reaction mixture heated at 90°-95° C. for 40 minutes

Sources & evidence

ORD record
ord-d67ed5b83c43496bb37db8483acfc053
Source dataset
uspto-grants-1994_04
Patent number
US05302720

Reaction notes

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