Ammonia → N-(5-fluoro-2-biphenylyl)thiourea

HRID 1464077Notes

Reaction equation

HRID 1464077 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:5]([N:14]=[C:15]=[S:16])=[CH:4][CH:3]=1.[NH3:17]>C(O)C>[F:1][C:2]1[CH:3]=[CH:4][C:5]([NH:14][C:15]([NH2:17])=[S:16])=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:7]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 190892755-Fluoro-2-biphenylylisothiocyanate

Product 1

HCID 19089310N-(5-fluoro-2-biphenylyl)thiourea

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Reaction of 5-fluoro-2-biphenylylisothiocyanate (9.3 g) in ethanol (40 ml) with 28% aqueous ammonia solution (80 ml) at ambient temperature for 24 hours gave N-(5-fluoro-2-biphenylyl)thiourea as a yellow solid (m.p. 188°-190° C.).

Sources & evidence

ORD record
ord-49ae6bb6666e4be4bac2137aae5eee5b
Source dataset
uspto-grants-1994_04
Patent number
US05302720

Reaction notes

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