Potassium Hydroxide → 5-Fluoro-2-biphenylylcyanamide

HRID 1464078Notes

Reaction equation

HRID 1464078 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([NH:14][C:15]([NH2:17])=S)=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:7]=1.[OH-].[K+].O.O.O.C([O-])(=O)C.[Pb+2].C([O-])(=O)C>O>[F:1][C:2]1[CH:3]=[CH:4][C:5]([NH:14][C:15]#[N:17])=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:7]=1

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 22456Lead diacetate trihydrateHCID 19089310N-(5-fluoro-2-biphenylyl)thiourea

Product 1

HCID 190892235-Fluoro-2-biphenylylcyanamide

Reagents, catalysts & solvents 1

HCID 962WaterSolvent3×

Procedure

A suspension of N-(5-fluoro-2-biphenylyl)thiourea (8 g) in water (40 ml) was reacted with a solution of potassium hydroxide (18.2 g) in water (40 ml), and a solution of lead acetate trihydrate (12.3 g) in water (70 ml). The reaction mixture heated at 90°-95° C. for 1 hour to give 5-fluoro-2-biphenylylcyanamide as a yellow oil.

Workup

  1. temperatureThe reaction mixture heated at 90°-95° C. for 1 hour

Sources & evidence

ORD record
ord-facaa8de4b9a44368ed1abe1408833f0
Source dataset
uspto-grants-1994_04
Patent number
US05302720

Reaction notes

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