Thiophosgene → 4-Methylthio-2-biphenylylisothiocyanate

HRID 1464084Notes

Reaction equation

HRID 1464084 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([S:8][CH3:9])[CH:5]=[CH:4][C:3]=1[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.[C:16](Cl)(Cl)=[S:17]>O1CCOCC1.O>[CH3:9][S:8][C:6]1[CH:7]=[C:2]([N:1]=[C:16]=[S:17])[C:3]([C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=2)=[CH:4][CH:5]=1

Participants

5

Reactant 2

HCID 10040ThiophosgeneHCID 190891962-Amino-4-methylthiobiphenyl

Product 1

HCID 190892824-Methylthio-2-biphenylylisothiocyanate

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 312751,4-DioxaneSolvent

Procedure

Reaction of 2-amino-4-methylthiobiphenyl (10.8 g) with thiophosgene (4.6 ml) in a mixture of dioxan (10 ml) and water (200 ml) at 10° C. and then at ambient temperature for 15 hours yielded 4-methylthio-2-biphenylylisothiocyanate as a yellow oil.

Sources & evidence

ORD record
ord-1b0c6b8c961540109926ec7f5150e84c
Source dataset
uspto-grants-1994_04
Patent number
US05302720

Reaction notes

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