Methyl iodide → HCID 178488544, compound

HRID 1464117Notes

Reaction equation

HRID 1464117 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[NH:15][C:16]([NH2:18])=[S:17])=[CH:5][CH:4]=1.[CH3:19][I:20]>CO>[IH:20].[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[NH:15][C:16](=[NH:18])[S:17][CH3:19])=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 19089272HCID 19089272, compound

Product 1

HCID 178488544HCID 178488544, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Reaction of N-(4'-methoxy-2-biphenylyl)thiourea (14.7 g) with methyliodide (9.3 g) in methanol (60 ml) at gentle reflux on a hot water bath for 3 hours gave 1-(4'-methoxy-2-biphenylyl)-2-methyl-2-thiopseudourea hydroiodide as a semisolid. Reaction of the above hydroiodide (8 g) in dichloromethane (100 ml) with 10% aqueous sodium hydroxide solution (25 ml) at 0° C. gave 1-(4'-methoxy-2-biphenylyl)-2-methyl-2-thiopseudourea as a pale yellow solid (m.p. 94°-96° C.).

Workup

  1. temperatureat gentle reflux on a hot water bath for 3 hours

Sources & evidence

ORD record
ord-23532ff161b048aab1274c11047ef202
Source dataset
uspto-grants-1994_04
Patent number
US05302720

Reaction notes

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