Methyl iodide → HCID 178488544, compound

Participants

Reaction Steps

Reaction of N-(4'-methoxy-2-biphenylyl)thiourea (14.7 g) with methyliodide (9.3 g) in methanol (60 ml) at gentle reflux on a hot water bath for 3 hours gave 1-(4'-methoxy-2-biphenylyl)-2-methyl-2-thiopseudourea hydroiodide as a semisolid. Reaction of the above hydroiodide (8 g) in dichloromethane (100 ml) with 10% aqueous sodium hydroxide solution (25 ml) at 0° C. gave 1-(4'-methoxy-2-biphenylyl)-2-methyl-2-thiopseudourea as a pale yellow solid (m.p. 94°-96° C.).

Provenance & Evidence