Ammonium Hydroxide → 5-Chlorothiophene-2-Sulfonamide

HRID 1464121Notes

Reaction equation

HRID 1464121 reaction equation
[Cl:1][C:2]1[S:6][C:5]([S:7](Cl)(=[O:9])=[O:8])=[CH:4][CH:3]=1.[OH-].[NH4+:12]>>[Cl:1][C:2]1[S:6][C:5]([S:7]([NH2:12])(=[O:9])=[O:8])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 27339255-Chlorothiophene-2-sulfonyl chloride

Product 1

HCID 12413015-Chlorothiophene-2-Sulfonamide

Procedure

5-Chloro-2-thiophenesulfonyl chloride (4 g, 18.4 mmole) was added to ammonium hydroxide (100 ml of conc. aqueous solution). This mixture was stirred at room temperature and concentrated under vacuum. The precipitate was filtered and washed with hexanes and water to produce 1.94 g of solid.

Workup

  1. concentrationconcentrated under vacuum
  2. filtrationThe precipitate was filtered
  3. washwashed with hexanes and water

Sources & evidence

ORD record
ord-9110e2e978ac430dbc1bbcdb99669361
Source dataset
uspto-grants-1994_04
Patent number
US05302724

Reaction notes

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