Hydrochloric Acid → HCID 15669318, compound

HRID 1464122Notes

Reaction equation

HRID 1464122 reaction equation
[Cl:1][C:2]1[S:6][C:5]([S:7]([NH2:10])(=[O:9])=[O:8])=[CH:4][CH:3]=1.[OH-].[Na+].[Cl:13][C:14]1[CH:19]=[CH:18][C:17]([N:20]=[C:21]=[O:22])=[CH:16][CH:15]=1.Cl>CC(C)=O>[Cl:1][C:2]1[S:6][C:5]([S:7]([NH:10][C:21]([NH:20][C:17]2[CH:18]=[CH:19][C:14]([Cl:13])=[CH:15][CH:16]=2)=[O:22])(=[O:9])=[O:8])=[CH:4][CH:3]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 76934-Chlorophenyl IsocyanateHCID 14798Sodium HydroxideHCID 12413015-Chlorothiophene-2-Sulfonamide

Product 1

HCID 15669318HCID 15669318, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent2×

Procedure

To a solution of 5-chloro-2-thiophenesulfonamide 1.9 g, 10 mmole) in 10 ml of acetone was added aqueous sodium hydroxide (10 ml of 1N. 10 mmole) followed by a solution of 4-chlorophenyl isocyanate (1.54 g, 10 mmole) dissolved in 10 ml of acetone. This mixture was stirred at room temperature overnight. The reaction mixture was concentrated under vacuum and acidified with aqueous hydrochloric acid (10 ml of 1N, 10 mmole). The precipitate was filtered and the residue washed with hexanes and water. The solid was dried in a vacuum oven.

Workup

  1. concentrationThe reaction mixture was concentrated under vacuum
  2. filtrationThe precipitate was filtered
  3. washthe residue washed with hexanes and water
  4. customThe solid was dried in a vacuum oven

Sources & evidence

ORD record
ord-e0da1c8d98c74bd49fce1ba1112929aa
Source dataset
uspto-grants-1994_04
Patent number
US05302724

Reaction notes

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