Ammonium Hydroxide → HCID 15669341, compound

HRID 1464129Notes

Reaction equation

HRID 1464129 reaction equation
[CH3:1][C:2]1[S:3][CH:4]=[CH:5][C:6]=1[CH3:7].Cl[S:9]([OH:12])(=O)=[O:10].[OH-].[NH4+:14]>C(Cl)(Cl)Cl>[CH3:7][C:6]1[CH:5]=[C:4]([S:9]([NH2:14])(=[O:12])=[O:10])[S:3][C:2]=1[CH3:1]

Participants

5

Reactant 3

HCID 14923Ammonium HydroxideHCID 24638Chlorosulfonic acidHCID 342952,3-Dimethylthiophene

Product 1

HCID 15669341HCID 15669341, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

The procedure of Example 3A was followed with 2,3-dimethylthiophene (6.0 g, 53.6 mmole), chlorosulfonic acid (27.5 g), dry chloroform (160 ml total), and concentrated ammonium hydroxide to provide solid 4,5-dimethyl-2-thiophenesulfonamide. The sulfonamide (1.5 g, 7.7 mmole), 1N NaOH (7.7 ml), acetone (7.0 ml) were combined and 4-chlorophenyl isocyanate (1.14 g, 7.7 mmole), 1N HCl (7.7 ml) to provide the named product (1.0 g).

Sources & evidence

ORD record
ord-f4f1663272e2423bbf2945679bb48906
Source dataset
uspto-grants-1994_04
Patent number
US05302724

Reaction notes

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