Hydrochloric Acid → HCID 86747762, compound

Participants

Reaction Steps

1 ml of concentrated hydrochloric acid was added to a solution of 1.34 g of methyl 2-[(4,6-dimethoxypyrimidin-2-yl)-N-formylamino]-6-[1-(N-methoxyimino)ethyl]benzoate in 50 ml of methanol, and the mixture was allowed to stand at room temperature for one night. The reaction liquor was poured into an ice water, and was extracted with ethyl acetate. The organic layer thus formed was washed with sodium hydrogencarbonate aqueous solution and water in sequence, and was dried and concentrated. The residue thus obtained was purified by column chromatography to obtain 0.87 g of the aimed compound (melting point=82° to 84° C.) at a yield of 70%.

Provenance & Evidence