Hydrochloric Acid → HCID 86747762, compound

HRID 1464207Notes

Reaction equation

HRID 1464207 reaction equation
Cl.[CH3:2][O:3][C:4]1[CH:9]=[C:8]([O:10][CH3:11])[N:7]=[C:6]([N:12]([C:15]2[CH:24]=[CH:23][CH:22]=[C:21]([C:25](=[N:27][O:28][CH3:29])[CH3:26])[C:16]=2[C:17]([O:19][CH3:20])=[O:18])C=O)[N:5]=1>CO>[CH3:2][O:3][C:4]1[CH:9]=[C:8]([O:10][CH3:11])[N:7]=[C:6]([NH:12][C:15]2[CH:24]=[CH:23][CH:22]=[C:21]([C:25](=[N:27][O:28][CH3:29])[CH3:26])[C:16]=2[C:17]([O:19][CH3:20])=[O:18])[N:5]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86747763HCID 86747763, compound

Product 1

HCID 86747762HCID 86747762, compoundYield 70%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1 ml of concentrated hydrochloric acid was added to a solution of 1.34 g of methyl 2-[(4,6-dimethoxypyrimidin-2-yl)-N-formylamino]-6-[1-(N-methoxyimino)ethyl]benzoate in 50 ml of methanol, and the mixture was allowed to stand at room temperature for one night. The reaction liquor was poured into an ice water, and was extracted with ethyl acetate. The organic layer thus formed was washed with sodium hydrogencarbonate aqueous solution and water in sequence, and was dried and concentrated. The residue thus obtained was purified by column chromatography to obtain 0.87 g of the aimed compound (melting point=82° to 84° C.) at a yield of 70%.

Workup

  1. waitto stand at room temperature for one night
  2. extractionwas extracted with ethyl acetate
  3. customThe organic layer thus formed
  4. washwas washed with sodium hydrogencarbonate aqueous solution and water in sequence
  5. customwas dried
  6. concentrationconcentrated
  7. customThe residue thus obtained
  8. customwas purified by column chromatography

Sources & evidence

ORD record
ord-7d6b8dc3b5384189a5fc4eecd68c3297
Source dataset
uspto-grants-1994_04
Patent number
US05302739

Reaction notes

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