Hydrochloric Acid → HCID 131718392, compound

HRID 1464235Notes

Reaction equation

HRID 1464235 reaction equation
[NH2:1][C@H:2]([C:11]([O:13]CC)=O)[CH2:3][C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1.[NH2:16][C@H:17]([C:23]([O:25][CH2:26][CH3:27])=[O:24])[CH2:18][CH2:19][CH2:20][CH2:21][NH2:22].Cl>>[NH2:1][C@H:2]([C:11]([NH:16][C@H:17]([C:23]([O:25][CH2:26][CH3:27])=[O:24])[CH2:18][CH2:19][CH2:20][CH2:21][NH2:22])=[O:13])[CH2:3][C:4]1[CH:5]=[CH:6][C:7]([OH:10])=[CH:8][CH:9]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 70364L-Tyrosine ethyl esterHCID 107469L-Lysine ethyl ester

Product 1

HCID 131718392HCID 131718392, compound

Procedure

Mal-Tyr-Lys-OEt was prepared with CT as the catalyst in a 100 ml beaker with Mal-Tyr-OEt employed as the electrophile and Lys-OEt.2 HCl employed as the nucleophile. After a short time, the product separated out as a white precipitate and was filtered off, washed with water and dried in a vacuum at 50° C. The conditions and results employed are compiled in the following table:

Workup

  1. customAfter a short time, the product separated out as a white precipitate
  2. filtrationwas filtered off
  3. washwashed with water
  4. customdried in a vacuum at 50° C
  5. customThe conditions and results

Sources & evidence

ORD record
ord-831ed2883e0f4c3f8028939e7a44e706
Source dataset
uspto-grants-1994_04
Patent number
US05304470

Reaction notes

Loading…