Sodium Hydroxide → HCID 19087746, compound

HRID 1464270Notes

Reaction equation

HRID 1464270 reaction equation
C([O:3][C:4]([CH2:6][CH2:7][CH2:8][N:9]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[C:12](=[O:19])[NH:11][C:10]1=[O:20])=[O:5])C.[OH-].[Na+]>CO.O1CCCC1>[C:4]([CH2:6][CH2:7][CH2:8][N:9]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[C:12](=[O:19])[NH:11][C:10]1=[O:20])([OH:5])=[O:3]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 19087677HCID 19087677, compound

Product 1

HCID 19087746HCID 19087746, compoundYield 79.2%

Reagents, catalysts & solvents 1

HCID 21899815MeOH tetrahydrofuranSolvent

Procedure

A mixture of 1-(3-ethoxycarbonylpropyl)-2,4(1H,3H)-quinazolinedione (552 mg) and 1N sodium hydroxide (6.0 ml) in methanol-tetrahydrofuran (26 ml, 3.3:1 V/V) was stirred for 3 hours at room temperature. After evaporation of the organic solvents, the mixture was adjusted to pH 4~5 with 1N hydrochloric acid to give precipitates. Collected precipitates were washed in turn with water and ethanol to give 1-(3-carboxypropyl)-2,4(1H,3H)-quinazolinedione (393 mg) as a powder.

Workup

  1. customAfter evaporation of the organic solvents
  2. customto give
  3. customprecipitates
  4. customCollected
  5. customprecipitates
  6. washwere washed in turn with water and ethanol

Sources & evidence

ORD record
ord-9c928da4aa5c46dcb690f7b45a787d0a
Source dataset
uspto-grants-1994_04
Patent number
US05304560

Reaction notes

Loading…