Sodium Hydroxide → HCID 19087746, compound

Participants

Reaction Steps

A mixture of 1-(3-ethoxycarbonylpropyl)-2,4(1H,3H)-quinazolinedione (552 mg) and 1N sodium hydroxide (6.0 ml) in methanol-tetrahydrofuran (26 ml, 3.3:1 V/V) was stirred for 3 hours at room temperature. After evaporation of the organic solvents, the mixture was adjusted to pH 4~5 with 1N hydrochloric acid to give precipitates. Collected precipitates were washed in turn with water and ethanol to give 1-(3-carboxypropyl)-2,4(1H,3H)-quinazolinedione (393 mg) as a powder.

Provenance & Evidence