Hydrochloric Acid → 6H-Pyrrolo(2,3-d)pyrimidin-6-one, 5,7-dihydro-7-methyl-2-((1-methylethyl)amino)-, monohydrochloride

HRID 1464309Notes

Reaction equation

HRID 1464309 reaction equation
[CH:1]([NH:4][C:5]1[N:6]=[CH:7][C:8]2[CH2:13][C:12](=[O:14])[N:11]([CH3:15])[C:9]=2[N:10]=1)([CH3:3])[CH3:2].[ClH:16]>C1(C)C=CC=CC=1>[ClH:16].[CH:1]([NH:4][C:5]1[N:6]=[CH:7][C:8]2[CH2:13][C:12](=[O:14])[N:11]([CH3:15])[C:9]=2[N:10]=1)([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 3078645HCID 3078645, compound

Product 1

HCID 30786446H-Pyrrolo(2,3-d)pyrimidin-6-one, 5,7-dihydro-7-methyl-2-((1-methylethyl)amino)-, monohydrochlorideYield 92%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

0.49 g (2.4 mmoles) of 2-isopropylamino-5,6-dihydro-7-methyl-6-oxo(7H)pyrrolo[2,3-d]pyrimidine was dissolved in 30 ml of toluene, and hydrogen chloride gas was blown into the solution. The solution was concentrated under reduced pressure, and then washed with hexane to give 0.53 g (yield 92%) of the desired compound.

Workup

  1. concentrationThe solution was concentrated under reduced pressure
  2. washwashed with hexane

Sources & evidence

ORD record
ord-3dded2ac7259427a9f5fb20323cf0c63
Source dataset
uspto-grants-1994_04
Patent number
US05304555

Reaction notes

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