Maleic Acid → HCID 14517722, compound

HRID 1464310Notes

Reaction equation

HRID 1464310 reaction equation
[CH:1]([NH:4][C:5]1[N:6]=[CH:7][C:8]2[CH2:13][C:12](=[O:14])[N:11]([CH3:15])[C:9]=2[N:10]=1)([CH3:3])[CH3:2].[C:16]([OH:23])(=[O:22])/[CH:17]=[CH:18]\[C:19]([OH:21])=[O:20]>C(OCC)(=O)C>[C:16]([OH:23])(=[O:22])/[CH:17]=[CH:18]\[C:19]([OH:21])=[O:20].[CH:1]([NH:4][C:5]1[N:6]=[CH:7][C:8]2[CH2:13][C:12](=[O:14])[N:11]([CH3:15])[C:9]=2[N:10]=1)([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 444266Maleic AcidHCID 3078645HCID 3078645, compound

Product 1

HCID 14517722HCID 14517722, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

6.37 g (30.9 mmoles) of 2-isopropylamino-5,6-dihydro-7-methyl-6-oxo(7H)pyrrolo[2,3-d]pyrimidine was dissolved in 50 ml of ethyl acetate, and 3.58 g (30.8 mmoles) of maleic acid was added. The mixture was stirred at room temperature for 1 hour. The resulting crystals were collected by filtration to give 8.90 g (yield 90%) of the desired compound.

Workup

  1. filtrationThe resulting crystals were collected by filtration

Sources & evidence

ORD record
ord-256917aa915e4536ab0dd25d7146392c
Source dataset
uspto-grants-1994_04
Patent number
US05304555

Reaction notes

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