Piperidin-4-ol → HCID 14994956, compound

HRID 1464319Notes

Reaction equation

HRID 1464319 reaction equation
[C:1](=[O:15])([O-])[O:2][C:3]1([C:12]#[N:13])[CH:8]=CC=C[CH:4]1C(C)C.[OH:16][CH:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1>>[C:12]([C:3]([CH3:4])([O:2][C:1]([N:20]1[CH2:21][CH2:22][CH:17]([OH:16])[CH2:18][CH2:19]1)=[O:15])[CH3:8])#[N:13]

Participants

3

Reactant 2

HCID 79341Piperidin-4-olHCID 86746987HCID 86746987, compound

Product 1

HCID 14994956HCID 14994956, compoundYield 98.1%

Procedure

50 g of 1-cyano-1-methylethylphenyl carbonate and 25 g of 4-hydroxypiperidine were heated at 130° C. After completion of the reaction, the resulting product was purified by silica gel column chromatography (elution solvent: hexane:ethyl acetate=1:1-1:2-0:1), thereby obtaining 50.5 g of the intended compound.

Workup

  1. customAfter completion of the reaction
  2. customthe resulting product was purified by silica gel column chromatography (elution solvent: hexane:ethyl acetate=1:1-1:2-0:1)

Sources & evidence

ORD record
ord-b359a99fa69341219c1ca6a8e604c6eb
Source dataset
uspto-grants-1994_04
Patent number
US05304553

Reaction notes

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