反应详情

A solution of ethyl 2-[(2'-t-butoxycarbonylbiphenyl-4-yl)methylaminomethylene]-3-oxo-4-nonenate (1.59 g, 3.23 mmol) in DMF (20 ml) and was heated under reflux for 4 hours. After cooling, the reaction solution was concentrated in vacuo. The resulting residue was purified by column chromatography on silica gel. The column was eluted with ethyl acetate-hexane (7:3 to 8:2) to give 1.21 g (76.2%) of the title compound as an oil.

1. temperatureunder reflux for 4 hours
2. temperatureAfter cooling
3. concentrationthe reaction solution was concentrated in vacuo
4. customThe resulting residue was purified by column chromatography on silica gel
5. washThe column was eluted with ethyl acetate-hexane (7:3 to 8:2)