Hydrochloric Acid → 2-[3-Fluoro-4-(quinolin-2-yl-methoxy)phenyl]-acetic acid

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Reaction Steps

25 g (0.077 mol) of the compound from Example XIV are dissolved in 300 ml of methanol and 125 ml of 1 molar sodium hydroxide solution are added. The mixture is stirred at the boiling point for 3 h, allowed to cool and neutralised with 1N hydrochloric acid. The whole is evaporated to dryness in vacuo, and covered with 50 ml of water and with 150 ml of dichloromethane. The dichloromethane phase is dried and the solvent is evaporated in vacuo. Colourless crystals remain.

Provenance & Evidence