Hydrochloric Acid → HCID 19087795, compound

HRID 1464377Notes

Reaction equation

HRID 1464377 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:20][C:21]([O:23]C)=[O:22])[CH:5]=[CH:6][C:7]=1[O:8][CH2:9][C:10]1[CH:19]=[CH:18][C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]=1.[OH-].[Na+].Cl>CO>[F:1][C:2]1[CH:3]=[C:4]([CH2:20][C:21]([OH:23])=[O:22])[CH:5]=[CH:6][C:7]=1[O:8][CH2:9][C:10]1[CH:19]=[CH:18][C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 19087788HCID 19087788, compound

Product 1

HCID 19087795HCID 19087795, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

25 g (0.077 mol) of the compound from Example XIV are dissolved in 300 ml of methanol and 125 ml of 1 molar sodium hydroxide solution are added. The mixture is stirred at the boiling point for 3 h, allowed to cool and neutralised with 1N hydrochloric acid. The whole is evaporated to dryness in vacuo, and covered with 50 ml of water and with 150 ml of dichloromethane. The dichloromethane phase is dried and the solvent is evaporated in vacuo. Colourless crystals remain.

Workup

  1. temperatureto cool
  2. customThe whole is evaporated to dryness in vacuo
  3. dry with materialThe dichloromethane phase is dried
  4. customthe solvent is evaporated in vacuo

Sources & evidence

ORD record
ord-5e8b33da77ce455d9e7309992ef4891c
Source dataset
uspto-grants-1994_04
Patent number
US05304563

Reaction notes

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