Sodium Hydroxide → Methyl 2-[3-methoxy-4-(quinolin-2-yl-methoxy)phenyl]acetate

HRID 1464382Notes

Reaction equation

HRID 1464382 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:10][C:11]([O:13][CH3:14])=[O:12])[CH:6]=[CH:7][C:8]=1[OH:9].Cl[CH2:16][C:17]1[CH:26]=[CH:25][C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[N:18]=1.[OH-].[Na+]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:10][C:11]([O:13][CH3:14])=[O:12])[CH:6]=[CH:7][C:8]=1[O:9][CH2:16][C:17]1[CH:26]=[CH:25][C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[N:18]=1

Participants

4

Reactant 3

HCID 14798Sodium HydroxideHCID 203942-(Chloromethyl)quinolineHCID 85214Methyl 4-hydroxy-3-methoxyphenylacetate

Product 1

HCID 19087794Methyl 2-[3-methoxy-4-(quinolin-2-yl-methoxy)phenyl]acetate

Procedure

In analogy to the procedure of Example XIV, the title compound is prepared from 16 g (0.082 mol) of methyl 3-methoxy-4-hydroxyphenylacetate, 14.5 g (0.082 mol) of 2-chloromethylquinoline and 3.28 g (0.082 mol) of sodium hydroxide.

Sources & evidence

ORD record
ord-f8110b9fe690400ab97000d517150780
Source dataset
uspto-grants-1994_04
Patent number
US05304563

Reaction notes

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