Sodium Hydroxide → HCID 19087777, compound

HRID 1464384Notes

Reaction equation

HRID 1464384 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:4][C:3]=1[S:14][C:15]([F:18])([F:17])[F:16].Cl[CH2:20][C:21]1[CH:30]=[CH:29][C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[N:22]=1.[OH-].[Na+]>>[F:17][C:15]([F:18])([F:16])[S:14][C:3]1[CH:4]=[C:5]([CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:6]=[CH:7][C:2]=1[O:1][CH2:20][C:21]1[CH:30]=[CH:29][C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[N:22]=1

Participants

4

Reactant 3

HCID 14798Sodium HydroxideHCID 203942-(Chloromethyl)quinolineHCID 54018388HCID 54018388, compound

Product 1

HCID 19087777HCID 19087777, compound

Procedure

In analogy to the procedure of Example XIV, the title compound is prepared from 10 g (0.036 mol) of ethyl 4-hydroxy-3-trifluoromethylthiophenylacetate, 7.7 g (0.036 mol) of 2-chloromethylquinoline and 2.88 g (0.072 mol) of sodium hydroxide.

Sources & evidence

ORD record
ord-24df1218e3c0406fb3e16941253d524c
Source dataset
uspto-grants-1994_04
Patent number
US05304563

Reaction notes

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