2-Dimethylaminopyridine → HCID 19087780, compound

HRID 1464386Notes

Reaction equation

HRID 1464386 reaction equation
[F:1][C:2]([F:27])([F:26])[S:3][C:4]1[CH:5]=[C:6]([CH2:22][C:23](O)=[O:24])[CH:7]=[CH:8][C:9]=1[O:10][CH2:11][C:12]1[CH:21]=[CH:20][C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[N:13]=1.[CH3:28][S:29]([NH2:32])(=[O:31])=[O:30].Cl.C(N=C=NCCCN(C)C)C.CN(C1C=CC=CN=1)C>>[F:26][C:2]([F:1])([F:27])[S:3][C:4]1[CH:5]=[C:6]([CH2:22][C:23]([CH2:28][S:29]([NH2:32])(=[O:31])=[O:30])=[O:24])[CH:7]=[CH:8][C:9]=1[O:10][CH2:11][C:12]1[CH:21]=[CH:20][C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[N:13]=1

Participants

5

Reactant 4

HCID 218852-DimethylaminopyridineHCID 72879MethanesulfonamideHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 19087792HCID 19087792, compound

Product 1

HCID 19087780HCID 19087780, compound

Procedure

In analogy to the procedure of Example XV, the title compound is prepared from 1.2 g (3.1 mmol) of the compound from Example XXVI, 0.38 g (4 mmol) of methanesulphonamide, 0.77 g (4 mmol) of N-ethyl-N'-dimethylaminopropyl-carbodiimide hydrochloride and 0.49 g (4 mmol) of dimethylaminopyridine.

Sources & evidence

ORD record
ord-ab08592f2dd6490ca4e515efe326cd27
Source dataset
uspto-grants-1994_04
Patent number
US05304563

Reaction notes

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