Toluene → Methyl 2-[3-vinyl-4-(quinolin-2-yl-methoxy)phenyl]acetate

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Reaction Steps

200 mg (0.21 mmol) of the catalyst [P(phenyl)3 ]4Pd are weighed into a 50 ml brown glass flask (flushed with argon) and 2 g (5.2 mmol) of the compound from Example XX and 1.4 ml (5.2 mmol) of Bu3SnCH=CH2 (d=1.086), both dissolved in 10 ml of toluene, are added under argon. The mixture is heated to boiling for 20 hours with stirring in a light-protected apparatus. The solvent is then evaporated in vacuo and the residue is separated by column chromatography (silica gel 60, eluent: toluene/ethyl acetate=4:1).

Provenance & Evidence