Triethylamine → HCID 9849159, compound

HRID 1464403Notes

Reaction equation

HRID 1464403 reaction equation
[CH2:1]([C:5]1[CH:6]=[C:7]([CH:23]([CH:27]2[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]2)[C:24](O)=[O:25])[CH:8]=[CH:9][C:10]=1[O:11][CH2:12][C:13]1[CH:22]=[CH:21][C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[N:14]=1)[CH:2]([CH3:4])[CH3:3].S(Cl)(C)(=O)=O.[CH3:38][S:39]([NH2:42])(=[O:41])=[O:40].C(N(CC)CC)C.CN(C1C=CC=CN=1)C>>[CH3:38][S:39]([NH:42][C:24](=[O:25])[CH:23]([C:7]1[CH:8]=[CH:9][C:10]([O:11][CH2:12][C:13]2[CH:22]=[CH:21][C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[N:14]=2)=[C:5]([CH2:1][CH:2]([CH3:4])[CH3:3])[CH:6]=1)[CH:27]1[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]1)(=[O:41])=[O:40]

Participants

6

Reactant 5

HCID 8471TriethylamineHCID 218852-DimethylaminopyridineHCID 31297Methanesulfonyl chlorideHCID 72879MethanesulfonamideHCID 19025745HCID 19025745, compound

Product 1

HCID 9849159HCID 9849159, compound

Procedure

The title compound is prepared in analogy to the procedure of Example XVI from 3.5 g (0.008 mol) of the compound of Example 81, 1 g (0.008 mol) of mesyl chloride, 0.912 g of methanesulphonamide, 1.62 g (0.016 mol) of triethylamine and 0.98 g (0.008 mol) of dimethylaminopyridine.

Sources & evidence

ORD record
ord-659adacf557c46289cbed531381d59fc
Source dataset
uspto-grants-1994_04
Patent number
US05304563

Reaction notes

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