反应详情

A mixture of 4.2 g of the product of Step C., 40 ml of tetrahydrofuran and 2.7 g of N-bromo-succinimide was cooled to 0° C. and stirred for one hour at this temperature, then brought to dryness. The residue was chromatographed on silica, eluting with a hexane-ethyl acetate mixture (8-2) to obtain 1.9 g of the expected product. Thin layer chromatography; Rf=0.28 [eluant: hexane-ethyl acetate (8-2)].

1. customThe residue was chromatographed on silica
2. washeluting with a hexane-ethyl acetate mixture (8-2)