Thionyl Chloride → 4,5,6,7-Tetrahydro-benzo[b]thiophene-2-carbonyl chloride

HRID 1464429Notes

Reaction equation

HRID 1464429 reaction equation
[S:1]1[C:5]([C:6](O)=[O:7])=[CH:4][C:3]2[CH2:9][CH2:10][CH2:11][CH2:12][C:2]1=2.S(Cl)([Cl:15])=O>>[S:1]1[C:5]([C:6]([Cl:15])=[O:7])=[CH:4][C:3]2[CH2:9][CH2:10][CH2:11][CH2:12][C:2]1=2

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 20634434,5,6,7-Tetrahydro-1-benzothiophene-2-carboxylic acid

Product 1

HCID 64853624,5,6,7-Tetrahydro-benzo[b]thiophene-2-carbonyl chloride

Procedure

1.0 g of 4,5,6,7-tetrahydrobenzo[b]thiophene-2-carboxylic acid was reacted with 4 ml of thionyl chloride for 3.5 hours under reflux. Then, excess thionyl chloride was distilled off under reduced pressure to obtain 4,5,6,7-tetrahydrobenzo[b]thiophene-2-carbonyl chloride.

Workup

  1. temperatureunder reflux
  2. distillationThen, excess thionyl chloride was distilled off under reduced pressure

Sources & evidence

ORD record
ord-7fb9e1d23fca47a89f28e5f5c3d7c586
Source dataset
uspto-grants-1994_04
Patent number
US05304657

Reaction notes

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