Hydrochloric Acid → HCID 10427043, compound

HRID 1464484Notes

Reaction equation

HRID 1464484 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:17]3[C:12](=[C:13]([Cl:18])[CH:14]=[CH:15][CH:16]=3)[C:11](=[O:19])[C:10]([C:20]([O:22]C)=[O:21])=[N:9]2)=[CH:4][CH:3]=1.Cl.O>O1CCOCC1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:17]3[C:12](=[C:13]([Cl:18])[CH:14]=[CH:15][CH:16]=3)[C:11](=[O:19])[C:10]([C:20]([OH:22])=[O:21])=[N:9]2)=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 10904198HCID 10904198, compound

Product 1

HCID 10427043HCID 10427043, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To 10 g (28.6 mmole) of the above methyl ester (from step 2) in 150 ml of p-dioxane there is added 10 ml (4 eq.) of concentrated HCl with stirring under a nitrogen atmosphere. The mixture is heated up and refluxed for 5 hours. After cooling, the mixture is poured into water with stirring. Free acid is collected by filtration and dried over vacuum at 50° C. (9.5 g, 99%).

Workup

  1. temperatureThe mixture is heated up
  2. temperaturerefluxed for 5 hours
  3. temperatureAfter cooling
  4. stirringwith stirring
  5. filtrationFree acid is collected by filtration
  6. customdried over vacuum at 50° C. (9.5 g, 99%)

Sources & evidence

ORD record
ord-661eec0e3a564546a618626a1bdcc3f9
Source dataset
uspto-grants-1994_04
Patent number
US05304672

Reaction notes

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