Zinc Sulfate → HCID 178452756, compound

HRID 1464559Notes

Reaction equation

HRID 1464559 reaction equation
C(=O)([O-])O.[Na+].[CH2:6]([O:10][C:11]([NH:13][C:14]1[CH:15]=[C:16]([OH:23])[C:17](=[CH:21][CH:22]=1)[C:18]([OH:20])=[O:19])=[O:12])[CH2:7][CH2:8][CH3:9].S([O-])([O-])(=O)=O.[Zn+2:29]>>[CH2:6]([O:10][C:11]([NH:13][C:14]1[CH:15]=[C:16]([OH:23])[C:17](=[CH:21][CH:22]=1)[C:18]([O-:20])=[O:19])=[O:12])[CH2:7][CH2:8][CH3:9].[Zn+2:29].[CH2:6]([O:10][C:11]([NH:13][C:14]1[CH:15]=[C:16]([OH:23])[C:17](=[CH:21][CH:22]=1)[C:18]([O-:20])=[O:19])=[O:12])[CH2:7][CH2:8][CH3:9]

Participants

4

Reactant 3

HCID 24424Zinc SulfateHCID 516892Sodium BicarbonateHCID 10914094HCID 10914094, compound

Product 1

HCID 178452756HCID 178452756, compoundYield 91.3%

Procedure

To 400 ml of an aqueous solution containing 8.4 g of sodium hydrogen carbonate, 25.3 g of 4-(n-butyloxycarbonylamino)salicylic acid was gradually added and dissolved at room temperature. The solution obtained was dropwise added to 200 ml of an aqueous solution containing 14.9 g of zinc sulfate 7 hydrate over 20 minutes at room temperature. After finishing dropwise addition, the mixture was further stirred for 30 minutes. Precipitated crystals were filtered, washed with water, and dried to obtain 26 g of desired zinc 4-(n-butyloxycarbonylamino)salicylate.

Workup

  1. additionwas gradually added
  2. dissolutiondissolved at room temperature
  3. customThe solution obtained
  4. additionaddition
  5. customPrecipitated crystals
  6. filtrationwere filtered
  7. washwashed with water
  8. customdried

Sources & evidence

ORD record
ord-3120c1b809274c40b9398acccba16c82
Source dataset
uspto-grants-1994_04
Patent number
US05306688

Reaction notes

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