Hydroxyamine hydrochloride → HCID 19086873, compound

HRID 1464618Notes

Reaction equation

HRID 1464618 reaction equation
O=[C:2]1[CH2:7][CH2:6][N:5]([C:8]([C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[NH:16][C:15](=[O:20])[CH2:14][CH2:13]3)=[O:9])[CH2:4][CH2:3]1.[NH2:21][OH:22].Cl.C([O-])(=O)C.[Na+]>C(O)C.O>[OH:22][N:21]=[C:2]1[CH2:7][CH2:6][N:5]([C:8]([C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[NH:16][C:15](=[O:20])[CH2:14][CH2:13]3)=[O:9])[CH2:4][CH2:3]1

Participants

6

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 19086843HCID 19086843, compound

Product 1

HCID 19086873HCID 19086873, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

37 Grams of 6-(4-oxo-1-piperidylcarbonyl)-3,4- -dihydrocarbostyril, 30.3 g of hydroxylamine·hydrochloride and 83.5 g of sodium acetate were dissolved in 600 ml of ethanol and 300 ml of water, the mixture wa stirred overnight at room temperature. The crystals precipitated were collected by filtration, and recrystallized from ethanol to yield 16 g of 6-(4-hydroxylimino-1-piperidylcarbonyl)-3,4-dihydrocarbostyril.

Workup

  1. customThe crystals precipitated
  2. filtrationwere collected by filtration
  3. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-a57fa2adca5248cc84215716d94cf5b9
Source dataset
uspto-grants-1994_04
Patent number
US05306719

Reaction notes

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