Bromine → 3-Bromo-2-(p-chlorophenyl)-5-[(trifluoromethyl)thio]pyrrole

HRID 1464662노트

반응식

HRID 1464662 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:9][C:10]([S:13][C:14]([F:17])([F:16])[F:15])=[CH:11][CH:12]=2)=[CH:4][CH:3]=1.[Br:18]Br>C(Cl)(Cl)Cl>[Br:18][C:12]1[CH:11]=[C:10]([S:13][C:14]([F:15])([F:17])[F:16])[NH:9][C:8]=1[C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=1

참가 물질

4

반응물 2

HCID 24408BromineHCID 189304232-(p-Chlorophenyl)-5-[(trifluoromethyl)thio]pyrrole

생성물 1

HCID 189304073-Bromo-2-(p-chlorophenyl)-5-[(trifluoromethyl)thio]pyrrole수율 80.2%

시약·촉매·용매 1

HCID 6212Chloroform용매2회

실험 절차

A solution of 2-(p-chlorophenyl)-5-[(trifluoromethyl)thio]pyrrole (1.94 g, 0.00699 mol) in chloroform is cooled, treated with a solution of bromine (1.16 g, 0.00699 mol) in chloroform, stirred for two hours, washed with water and brine, dried over anhydrous magnesium sulfate and concentrated in vacuo to obtain a dark syrup. Flash chromatography of the syrup using silica gel and a 1:10 ethyl acetate/hexanes solution gives the title product as a pink syrup (2.0 g) which is identified by 1HNMR and 13CNMR spectral analyses.

후처리

  1. washwashed with water and brine
  2. dry with materialdried over anhydrous magnesium sulfate
  3. concentrationconcentrated in vacuo
  4. customto obtain a dark syrup

출처 및 근거

ORD 기록
ord-5f5cd7f121ba4b8db9cca4b1e0421ece
출처 데이터셋
uspto-grants-1994_04
특허 번호
US05306827

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