反应详情

To a mixture of 8-bromo-3-aminochroman (200 mg; 0.9 mmol) in CH2Cl2 (25 ml) and 10% aqueous Na2CO3 (25 ml) was added propionyl chloride (400 mg; 2.2 mmol) and the mixture was stirred for 2 hours. The phases were separated and the organic layer was dried (MgSO4). The solvent was evaporated and the crude amide was reduced with tetrabutylammonium borohydride (400 mg, 1.6 mmol) in a boiling (1:1)-mixture (50 ml) of dichloromethane and 1,2-dichloroethane overnight. The solution was extracted with water, dried (Na2SO4) and the solvent was evaporated yielding 140 mg (58%) of 8-bromo-3-(n-propylamino)chroman.

1. customThe phases were separated
2. dry with materialthe organic layer was dried (MgSO4)
3. customThe solvent was evaporated
4. extractionThe solution was extracted with water
5. dry with materialdried (Na2SO4)
6. customthe solvent was evaporated