Hydrofluoric Acid → 2-Fluoro-m-xylene

HRID 1464716Notes

Reaction equation

HRID 1464716 reaction equation
ClC(O[C:5]1[C:10]([CH3:11])=[CH:9][CH:8]=[CH:7][C:6]=1[CH3:12])=O.[FH:13]>>[CH3:12][C:6]1[CH:7]=[CH:8][CH:9]=[C:10]([CH3:11])[C:5]=1[F:13]

Participants

3

Reactant 2

HCID 14917Hydrofluoric AcidHCID 2716182,6-Dimethylphenyl carbonochloridate

Product 1

HCID 1230652-Fluoro-m-xyleneYield 68.4%

Conditions

Temperature
140 °C

Procedure

500 ml of anhydrous hydrogen fluoride were placed at 0° C. in a stainless steel laboratory autoclave and 150 g of 2,6-dimethylphenyl chloroformate were added dropwise. The autoclave was sealed and heated at a maximum temperature of 140° C. for 1.5 hours, the pressure of the gases formed being released at 26 bar. The reaction mixture was worked up as described in Example 9. 2,6-Dimethylfluorobenzene was obtained in a yield of 68.4%.

Workup

  1. additionwere added dropwise
  2. customThe autoclave was sealed
  3. customthe pressure of the gases formed

Sources & evidence

ORD record
ord-3978f870c5194451b59e56a0f7d7e5fb
Source dataset
uspto-grants-1994_04
Patent number
US05306849

Reaction notes

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