Hydrofluoric Acid → 2-Fluoro-m-xylene
Reaction equation
[FH:1].ClC(O[C:6]1[C:11]([CH3:12])=[CH:10][CH:9]=[CH:8][C:7]=1[CH3:13])=O>>[CH3:13][C:7]1[CH:8]=[CH:9][CH:10]=[C:11]([CH3:12])[C:6]=1[F:1]Participants
3
Conditions
- Temperature
- 130 °C
Procedure
1.1 kg of anhydrous hydrogen fluoride were placed in a 3 l autoclave and the autoclave was sealed and heated to 130° C. At this temperature, 1 kg of 2,6-dimethylphenyl chloroformate was pumped in over a period of 3 hours, the pressure of the gases formed being released at 40 bar. Finally, the mixture was stirred for 1 hour at 130° C. The reaction mixture was then cooled and excess hydrogen fluoride was distilled off at 100 mbar. Further working-up of the reaction mixture was carried out as described in Example 9. 2,6-Dimethylfluorobenzene was obtained in a yield of 58.3%.
Workup
- customthe autoclave was sealed
- customwas pumped in over a period of 3 hours
- customthe pressure of the gases formed
- temperatureThe reaction mixture was then cooled
- distillationexcess hydrogen fluoride was distilled off at 100 mbar
Sources & evidence
- ORD record
- ord-685a5566410848a4ac1a06d910f32a26
- Source dataset
- uspto-grants-1994_04
- Patent number
- US05306849
Reaction notes
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