2-Hepten-4-yne, 1-bromo-6,6-dimethyl- → (E)-N-(6-methoxy-6-methyl-2-hepten-4-ynyl)-5-[3-(3-thienyl)phenoxy]pentylamine

HRID 1464742노트

반응식

HRID 1464742 반응식
S1C=CC(C2C=C(C=CC=2)OCCOCCN)=C1.CC(C)(C)C#C/C=C/CBr.[S:29]1[CH:33]=[CH:32][C:31]([C:34]2[CH:35]=[C:36]([CH:44]=[CH:45][CH:46]=2)[O:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][NH2:43])=[CH:30]1.[CH3:47][O:48][C:49]([CH3:57])([CH3:56])[C:50]#[C:51]/[CH:52]=[CH:53]/[CH2:54]Br>>[CH3:47][O:48][C:49]([CH3:57])([CH3:56])[C:50]#[C:51]/[CH:52]=[CH:53]/[CH2:54][NH:43][CH2:42][CH2:41][CH2:40][CH2:39][CH2:38][O:37][C:36]1[CH:44]=[CH:45][CH:46]=[C:34]([C:31]2[CH:32]=[CH:33][S:29][CH:30]=2)[CH:35]=1

참가 물질

5

반응물 4

HCID 110744282-Hepten-4-yne, 1-bromo-6,6-dimethyl-HCID 13647222(E)-6-methoxy-6-methyl-2-hepten-4-ynyl bromideHCID 199169515-[3-(3-Thienyl)phenoxy]pentylamineHCID 199170062-[2-[3-(3-Thienyl)phenoxy]ethoxy]ethylamine

생성물 1

HCID 19916981(E)-N-(6-methoxy-6-methyl-2-hepten-4-ynyl)-5-[3-(3-thienyl)phenoxy]pentylamine

실험 절차

Compound of Example 53 was obtained by performing the same reaction as in Example 52 except that 2-[2-[3-(3-thienyl)phenoxy]ethoxy]ethylamine and (E)-6,6-dimethyl-2-hepten-4-ynyl bromide were used instead of the starting compounds, 5-[3-(3-thienyl)phenoxy]pentylamine and (E)-6-methoxy-6-methyl-2-hepten-4-ynyl bromide, which were used in the above-mentioned reaction.

후처리

  1. customwere used in the above-mentioned reaction

출처 및 근거

ORD 기록
ord-9c66eff8cabf42c4a8e8d327f8fa373a
출처 데이터셋
uspto-grants-1994_04
특허 번호
US05306728

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