Malonic Acid → HCID 56929678, compound

HRID 1464940Notes

Reaction equation

HRID 1464940 reaction equation
[C:1]([OH:7])(=[O:6])[CH2:2][C:3]([OH:5])=[O:4].[Cl:8][C:9]1[CH:10]=[CH:11][C:12]2[CH2:18][CH2:17][NH:16][CH2:15][C@H:14]([CH3:19])[C:13]=2[CH:20]=1>ClC1C=CC2CCNC[C@](C)(C(C(O)=O)C(O)=O)C=2C=1.C(OC(C)C)(=O)C>[C:1]([OH:7])(=[O:6])[CH2:2][C:3]([OH:5])=[O:4].[Cl:8][C:9]1[CH:10]=[CH:11][C:12]2[CH2:18][CH2:17][NH:16][CH2:15][C@H:14]([CH3:19])[C:13]=2[CH:20]=1

Participants

4

Reactant 2

HCID 867Malonic AcidHCID 11658860Lorcaserin

Product 1

HCID 56929678HCID 56929678, compound

Reagents, catalysts & solvents 1

HCID 131732659HCID 131732659, compoundSolvent

Procedure

(R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine malonate salt was prepared by addition of malonic acid (1 eq.) to a solution of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine in isopropyl acetate. (R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine malonate salt had an extrapolated melting onset temperature by DSC of about 143° C.

Workup

  1. customby DSC of about 143° C.

Sources & evidence

ORD record
ord-2953559423f94078844955018ca3de24
Source dataset
uspto-grants-2015_04
Patent number
US08999970B2

Reaction notes

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