反应详情

A mixture of tert-butyl 4-(6-cyclobutoxypyrimidin-4-yl)piperazine-1-carboxylate (687 mg, 2.06 mmol) and 4 M HCl-EtOAc (30 ml) were stirred at rt for 2 h. Then EtOAc was added, and the solvent was removed in vacuo. The residue was suspended in EtOAc, and the white precipitate was collected by filtration to give 525 mg (quant) of the title compound as a white solid. The compound was used for the next step without further purification.

1. customthe solvent was removed in vacuo
2. filtrationthe white precipitate was collected by filtration