Potassium Carbonate → HCID 56654485, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-chloro-1-(4-(6-isobutoxypyrimidin-4-yl)piperazin-1-yl)ethanone (20 mg, 0.064 mmol), quinolin-5-ol (10.2 mg, 0.070 mmol), and potassium carbonate (18 mg, 0.13 mmol) in DMF was (0.5 mL) was stirred at 90° C. for 3 h. After cooling to rt, the mixture was poured onto water, and the aqueous later was extracted with dichloromethane (three times). The combined organic layer was dried over sodium sulfate and concentrated in vacuo. The residue was purified by preparative LC-MS to give 9.3 mg (34% yields) of the title compound.

Provenance & Evidence