反应详情

温度

90 °C

A mixture of 2-chloro-1-(4-(6-isobutoxypyrimidin-4-yl)piperazin-1-yl)ethanone (20 mg, 0.064 mmol), quinolin-5-ol (10.2 mg, 0.070 mmol), and potassium carbonate (18 mg, 0.13 mmol) in DMF was (0.5 mL) was stirred at 90° C. for 3 h. After cooling to rt, the mixture was poured onto water, and the aqueous later was extracted with dichloromethane (three times). The combined organic layer was dried over sodium sulfate and concentrated in vacuo. The residue was purified by preparative LC-MS to give 9.3 mg (34% yields) of the title compound.

1. temperatureAfter cooling to rt
2. additionthe mixture was poured onto water
3. extractionthe aqueous later was extracted with dichloromethane (three times)
4. dry with materialThe combined organic layer was dried over sodium sulfate
5. concentrationconcentrated in vacuo
6. customThe residue was purified by preparative LC-MS
7. customto give