Phosphorus oxychloride → 7-Bromo-4-chlorothieno[3,2-d]pyrimidine

Participants

Reaction Conditions

Reaction Steps

7-Bromothieno[3,2-d]pyrimidine-4(3H)-one (5.9 g) was dissolved in POCl3 (20 mL) and then stirred at 150° C. for 3 hours. After cooling down to room temperature, the remaining POCl3 was concentrated and added to ice water to obtain a solid. The solid was washed with sat. NaHCO3 solution and dried with N2 gas to obtain the title compound.

Provenance & Evidence