反应详情

温度

150 °C

7-Bromothieno[3,2-d]pyrimidine-4(3H)-one (5.9 g) was dissolved in POCl3 (20 mL) and then stirred at 150° C. for 3 hours. After cooling down to room temperature, the remaining POCl3 was concentrated and added to ice water to obtain a solid. The solid was washed with sat. NaHCO3 solution and dried with N2 gas to obtain the title compound.

1. temperatureAfter cooling down to room temperature
2. concentrationthe remaining POCl3 was concentrated
3. additionadded to ice water
4. customto obtain a solid
5. washThe solid was washed with sat. NaHCO3 solution
6. dry with materialdried with N2 gas