反应详情

温度

100 °C

7-Bromo-4-chlorothieno[3,2-d]pyrimidine (5 g, 20.17 mmol) obtained in Step 3 of Preparation Example 1 and 2.0M NH3 dissolved in isopropanol solution (50 mL) were added to a sealed reaction vessel and stirred at 100° C. for 12 hours. The reaction mixture was cooled to room temperature and filtered to obtain a solid. The solid was washed with water and dried with N2 gas to obtain the title compound (3.8 g, 83%) without further purification.

1. additionwere added to a sealed reaction vessel
2. temperatureThe reaction mixture was cooled to room temperature
3. filtrationfiltered
4. customto obtain a solid
5. washThe solid was washed with water
6. dry with materialdried with N2 gas