Formamide → 7-methyl-3H,4H-thieno[3,2-d]pyrimidin-4-one

HRID 1465000Notes

Reaction equation

HRID 1465000 reaction equation
[NH2:1][C:2]1[C:6]([CH3:7])=[CH:5][S:4][C:3]=1[C:8]([O:10]C)=O.[CH:12]([NH2:14])=O>O>[CH3:7][C:6]1[C:2]2[N:1]=[CH:12][NH:14][C:8](=[O:10])[C:3]=2[S:4][CH:5]=1

Participants

4

Reactant 2

HCID 713FormamideHCID 123584Methyl 3-amino-4-methylthiophene-2-carboxylate

Product 1

HCID 1354396367-methyl-3H,4H-thieno[3,2-d]pyrimidin-4-one

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
200 °C

Procedure

Methyl 3-amino-4-methylthiophene-2-carboxylate (3.0 g) was added to formamide (5 mL), and the mixture was stirred at 200° C. for 3 hours. After cooling to room temperature water (50 mL) was added thereto and then stirred for 15 hours at room temperature to obtain a solid. The solid was filtered, washed with water and dried with N2 gas to obtain the title compound as a white solid without further purification.

Workup

  1. additionwas added
  2. stirringstirred for 15 hours at room temperature
  3. customto obtain a solid
  4. filtrationThe solid was filtered
  5. washwashed with water
  6. dry with materialdried with N2 gas

Sources & evidence

ORD record
ord-c1e28090ecd14663a1b12d7c0f0f4ba4
Source dataset
uspto-grants-2015_04
Patent number
US08999973B2

Reaction notes

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