反应详情

温度

200 °C

Methyl 3-amino-4-methylthiophene-2-carboxylate (3.0 g) was added to formamide (5 mL), and the mixture was stirred at 200° C. for 3 hours. After cooling to room temperature water (50 mL) was added thereto and then stirred for 15 hours at room temperature to obtain a solid. The solid was filtered, washed with water and dried with N2 gas to obtain the title compound as a white solid without further purification.

1. additionwas added
2. stirringstirred for 15 hours at room temperature
3. customto obtain a solid
4. filtrationThe solid was filtered
5. washwashed with water
6. dry with materialdried with N2 gas