Formamide → 7-methyl-3H,4H-thieno[3,2-d]pyrimidin-4-one

Participants

Reaction Conditions

Reaction Steps

Methyl 3-amino-4-methylthiophene-2-carboxylate (3.0 g) was added to formamide (5 mL), and the mixture was stirred at 200° C. for 3 hours. After cooling to room temperature water (50 mL) was added thereto and then stirred for 15 hours at room temperature to obtain a solid. The solid was filtered, washed with water and dried with N2 gas to obtain the title compound as a white solid without further purification.

Provenance & Evidence