HCID 67328188, compound → HCID 67327584, compound

HRID 1465020Notes

Reaction equation

HRID 1465020 reaction equation
[NH2:1][C:2]1[C:3]2[S:10][CH:9]=[C:8]([C:11]([NH:13][C:14]3[CH:19]=[C:18]([N+:20]([O-])=O)[CH:17]=[CH:16][C:15]=3[CH3:23])=[O:12])[C:4]=2[N:5]=[CH:6][N:7]=1>[Pd].CO>[NH2:1][C:2]1[C:3]2[S:10][CH:9]=[C:8]([C:11]([NH:13][C:14]3[CH:19]=[C:18]([NH2:20])[CH:17]=[CH:16][C:15]=3[CH3:23])=[O:12])[C:4]=2[N:5]=[CH:6][N:7]=1

Participants

4

Reactant 1

HCID 67328188HCID 67328188, compound

Product 1

HCID 67327584HCID 67327584, compoundYield 16.9%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

The compound (1 g, 3.0 mmol) obtained in Step 2 of Example 39 was added to methanol (15 mL) and Pd/C (200 mg), and stirred under H2 atmosphere for 14 hours at room temperature. The reaction mixture was filtered using Celite and concentrated to obtain the title compound (152 mg).

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-355f9a94e3ea4d34a17ac85a6095e5dc
Source dataset
uspto-grants-2015_04
Patent number
US08999973B2

Reaction notes

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