HRID1465031

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：Cc1ccc(N)cc1NC(=O)c1csc2c(NC3CC3)ncnc12

HCID67360673

N-(5-Amino-2-methylphenyl)-4-(cyclopropylamino)thieno[3,2-d]pyrimidine-7-carboxamide

C17H17N5OS

HCID68678664

未命名化合物

PRODUCTS

生成物

结构：Cc1cn(-c2ccc(C(=O)Nc3ccc(C)c(NC(=O)c4csc5c(NC6CC6)ncnc45)c3)cc2C(F)(F)F)cn1

HCID67360528

未命名化合物

PROCEDURE

实验过程

The procedure of Step 5 of Example 1 was repeated except for using N-(5-amino-2-methylphenyl)-4-(cyclopropylamino)thieno[3,2-d]pyrimidine-7-carboxamide and 4-(4-methyl-1H-imidazole-1-yl)-3-(trifluoromethyl)benzoic acid to obtain the title compound.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-03b9544da5f7435e8c6c3e5c42ae0f4c
来源数据集: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08999973B2
来源说明: uspto-grants-2015_04

反应 SMILES

[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:24])=[C:6]([NH:8][C:9]([C:11]2[C:15]3[N:16]=[CH:17][N:18]=[C:19]([NH:20][CH:21]4[CH2:23][CH2:22]4)[C:14]=3[S:13][CH:12]=2)=[O:10])[CH:7]=1.[CH3:25][C:26]1[N:27]=[CH:28][N:29]([C:31]2[CH:39]=[CH:38][C:34]([C:35](O)=[O:36])=[CH:33][C:32]=2[C:40]([F:43])([F:42])[F:41])[CH:30]=1>>[CH:21]1([NH:20][C:19]2[C:14]3[S:13][CH:12]=[C:11]([C:9]([NH:8][C:6]4[CH:7]=[C:2]([NH:1][C:35](=[O:36])[C:34]5[CH:38]=[CH:39][C:31]([N:29]6[CH:30]=[C:26]([CH3:25])[N:27]=[CH:28]6)=[C:32]([C:40]([F:41])([F:43])[F:42])[CH:33]=5)[CH:3]=[CH:4][C:5]=4[CH3:24])=[O:10])[C:15]=3[N:16]=[CH:17][N:18]=2)[CH2:22][CH2:23]1