Trifluoroacetic acid → HCID 86713381, compound

HRID 1465044Notes

Reaction equation

HRID 1465044 reaction equation
[CH3:1][O:2][C:3]1[C:4]([N+:12]([O-])=O)=[C:5]([CH:9]=[CH:10][CH:11]=1)[C:6]([OH:8])=O.[C:15](O)([C:17](F)(F)F)=O>O.CC#N>[NH2:12][C:4]1[C:3]([O:2][CH3:1])=[CH:11][CH:10]=[CH:9][C:5]=1[C:6]([C:11]1[CH:10]=[C:15]([CH3:17])[CH:5]=[CH:4][CH:3]=1)=[O:8]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 786323-Methoxy-2-nitrobenzoic acid

Product 1

HCID 86713381HCID 86713381, compound

Reagents, catalysts & solvents 1

HCID 18373917Acetonitrile--water (1/1)Solvent

Procedure

Intermediate A-19 was prepared from 3-methoxy-2-nitrobenzoic acid according to the general synthetic procedure described for Intermediate A-18. HPLC RT=2.21 min (H2O/CH3CN with TFA, Sunfire C18 3.5 μm, 2.1×30 mm, gradient=2 min, wavelength=220 nm). [M+H+]=246.

Sources & evidence

ORD record
ord-4d28ef3564eb42ea9a04375eeb6f21ce
Source dataset
uspto-grants-2015_04
Patent number
US08999918B2

Reaction notes

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