Methyl iodide → Ethyl 1-(4-fluorophenyl)-4-methoxy-pyrazole-3-carboxylate

HRID 1465188Notes

Reaction equation

HRID 1465188 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]=[C:11]([OH:13])[C:10]([C:14]([O:16][CH2:17][CH3:18])=[O:15])=[N:9]2)=[CH:4][CH:3]=1.[CH3:19]I>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH:12]=[C:11]([O:13][CH3:19])[C:10]([C:14]([O:16][CH2:17][CH3:18])=[O:15])=[N:9]2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 730292Ethyl 1-(4-fluorophenyl)-4-hydroxy-1H-pyrazole-3-carboxylate

Product 1

HCID 66611500Ethyl 1-(4-fluorophenyl)-4-methoxy-pyrazole-3-carboxylate

Procedure

E1 was prepared from D1 following the general procedure reported in Preparative Example 16 Step 2 using methyl iodide for the alkylation. MS (ES) C13H13FN2O3 requires: 264. Found: 265 (M+H)+ and 287 (M+Na)+.

Sources & evidence

ORD record
ord-7ff40aef26c04777b8e32f8a756de766
Source dataset
uspto-grants-2015_04
Patent number
US08999982B2

Reaction notes

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